Parâmetros laboratoriais em pessoas transgênero sob hormonioterapia: uma revisão narrativa
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Abstract
Hormone therapy significantly influences various laboratory parameters in transgender individuals, who experience physiological and metabolic changes throughout the transition process. This study presents a narrative review based on materials available in the PubMed, Virtual Health Library (BVS), and SciELO databases, covering publications from 2015 to 2025 in Portuguese, English, and Spanish. The topics addressed include hematological, lipid, hepatic, renal, and hormonal laboratory alterations related to transgender individuals. The literature indicates that testosterone administration in transgender men increases hemoglobin, hematocrit, and muscle mass, while in transgender women, estrogen promotes breast development, body fat redistribution, and reduction of masculine traits. Changes in lipid profiles, hepatic, renal, and glycemic functions were also reported, emphasizing the need for continuous clinical and laboratory monitoring. Furthermore, there are no specific reference values for transgender individuals in public or private health guidelines, which may lead to misinterpretations. It is also essential to highlight the social and institutional challenges faced by transgender people, such as discrimination and the lack of professional preparedness, which hinder adequate healthcare and treatment access.
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