Pathophysiological analysis of thrombophilia in pregnant women.
Main Article Content
Abstract
Thrombophilia can be defined as hemostatic disorders where there is an increase of prothrombotic factors, which may result in venous or arterial thrombosis. Thrombophilia can be divided into two groups: hereditary and acquired. Pregnancy naturally constitutes a state of hypercoagulability preparing for childbirth, decreasing fibrinolytic activity and increasing platelet aggregation. Thus, pregnant women diagnosed with thrombophilia may develop more clinical problems than non-pregnant women. This study aimed to describe the thrombophilias of higher incidence in pregnant women, their clinical manifestations, the main diagnostic methods and the profile of the women tested. Studies on the subject were identified by searching the databases PUBMED, SciELO, Latin American and Caribbean Literature on Health Sciences (LILACS), Google Scholar, books and manuals from government institutions focused on the health area. After analysis of the articles studied, protein S deficiency, factor V Leiden mutation, hyperhomocysteinemia and antiphospholipid syndrome were the most recurrent thrombophilias diagnosed in pregnant women, and the most common obstetric manifestations were: previous and recurrent abortion, fetal growth restriction, severe preeclampsia, occurrence of venous thromboembolism (VTE) and deep vein thrombosis (DVT). Cost-effectiveness have pointed out that the mass use of tests for the diagnosis of thrombophilia have not been effective in reducing and preventing deaths or obstetric disorders. Therefore, it is necessary that the exams be carried out in a carefully selected public, so that the correct prophylaxis and treatments are applied.
Article Details
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Statement - Policy Proposal for Open Access Journals
Authors who publish in The Brazilian journal of Biomedical Sciences (RBCBM) agree to the following terms: 1 - Authors retain the copyright and grant the journal the right to first publication, with the work simultaneously licensed under the Creative Commons Attribution License allowing sharing of the work with recognition of the authorship of the work and initial publication in this journal. 2 - Authors are authorized to assume additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal. 3 - Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes, as well as increase the impact and citation of published work.
This is an open access article under the CC-BY license